Gene knockdown in non-human primates

SILENCE THERAPEUTICS PLC

Gene knockdown in non-human primates

28 April 2014

Silence Therapeutics is pleased to announce that it has successfully shown gene knockdown in non-human primates using its RNA lung delivery system, DACC. This confirms that Silence Therapeutics has a broad delivery capability in RNA Therapeutics with validated delivery systems in the lung and the vasculature in vitro, in rodents and in non-human primates. The company's systemic vasculature delivery system, AtuPlex, is also currently being used in human clinical trials with an excellent safety profile.

Silence's Chief Executive Officer Ali Mortazavi said:

"The translation of our rodent data in DACC to non-human primates is a significant milestone. We have a broad and diversified technology platform from which to capitalise on our promise of becoming a product company. The ability to deliver RNA payloads to multiple tissues gives us a wide variety of choice from which to build a drug pipeline."

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