Oxford Biomedica Regulatory News (OXB)

For filings with the FCA include the annex

For filings with issuer exclude the annex

TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESi

1. Identity of the issuer or the underlying issuerof existing shares to which voting rights areattached: ii

Oxford Biomedica plc

2 Reason for the notification (please tick the appropriate box or boxes):

An acquisition or disposal of voting rights

An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments

An event changing the breakdown of voting rights

Other (please specify):

NOTIFICATION PROMPTED BY THE REMOVAL OF STOCK LENDING EXEMPTION FOLLOWING IMPLEMENTATION OF THE EU TRANSPARENCY DIRECTIVE AMENDMENTS

√

3. Full name of person(s) subject to thenotification obligation: iii

Aviva plc & its subsidiaries

4. Full name of shareholder(s)  (if different from 3.):iv

Registered Holder:

BNY Norwich Union Nominees Limited 12,653,207*

Chase (GA Group) Nominees Limited 179,452,317*

State Street Nominees Limited 1,175,468*

*denotes direct interest

Chase (GA Group) Nominees Limited 20,807,732

Chase Nominees Limited 6,571,927

Vidacos Nominees Limited 11,939,558

5. Date of the transaction and date onwhich the threshold is crossed orreached: v

25 November 2015

6. Date on which issuer notified:

27 November 2015

7. Threshold(s) that is/are crossed orreached: vi, vii

8% to 7% Change at Direct Interest Level

8. Notified details:

A: Voting rights attached to shares viii, ix

Class/type ofshares

if possible usingthe ISIN CODE

Situation previousto the triggeringtransaction

Resulting situation after the triggering transaction

NumberofShares

NumberofVotingRights

Numberof shares

Number of votingrights

% of voting rights x

Direct

Direct xi

Indirect xii

Direct

Indirect

Ordinary Shares

GB00066458157

250,089,544

250,089,544

232,600,209

193,280,992

39,319,217

7.51%

1.53%

B: Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financialinstrument

Expirationdate xiii

Exercise/Conversion Period xiv

Number of votingrights that may beacquired if theinstrument isexercised/ converted.

% of votingrights

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments xv, xvi

Resulting situation after the triggering transaction

Type of financialinstrument

Exercise price

Expiration date xvii

Exercise/Conversion period xviii

Number of voting rights instrument refers to

% of voting rights xix, xx

RIGHT TO RECALL LOANED SHARES

N/A

N/A

N/A

22,115,559*

* Direct interest

Nominal

Delta

0.86%

Total (A+B+C)

Number of voting rights

Percentage of voting rights

254,715,768

9.90%

9. Chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held, if applicable: xxi

The voting rights are managed and controlled by Aviva Investors Global Services Limited, with the following chain of controlled undertakings:-

Aviva Investors Global Services Limited:

· Aviva plc (Parent Company)

· Aviva Group Holdings Limited (wholly owned subsidiary of Aviva plc)

· Aviva Investors Holdings Limited (wholly owned subsidiary of Aviva Group Holdings Limited)

· Aviva Investors Global Services Limited (wholly owned subsidiary of Aviva Investors Holdings Limited)

Proxy Voting:

10. Name of the proxy holder:

See Section 4

11. Number of voting rights proxy holder will cease to hold:

12. Date on which proxy holder will cease to hold voting rights:

13. Additional information:

Figures are based the total number of voting rights of 2,574,040,687 as per the Company's Total Voting Rights Announcement of 2 November 2015.

14. Contact name:

Tim Watts

Chief Financial Officer, Oxford BioMedica

15. Contact telephone number:

+44 (0) 1865 783 000