Oxford Biomedica Regulatory News (OXB)

Oxford BioMedica plc ("the Company")

Directors' Interest in Shares

Oxford BioMedica (OXB:L): the Company announces that Dr Paul Blake, a director of the Company, bought 100,000 1p ordinary shares of Oxford BioMedica plc on 15 December 2011 at a price of 3.35p per share.

Following this share purchase, Dr Paul Blake holds 200,000 1p ordinary shares of Oxford BioMedica plc, representing 0.02% of the current issued share capital.

For information, Oxford BioMedica plc currently has 944,875,557 1p ordinary shares in issue

Andrew Wood

Company Secretary, Oxford BioMedica plc

16 December 2011