Banco Santander Regulatory News (BNC)

1.

Name of the issuer

BANCO SANTANDER, S.A.

2.

State whether the notification relates to (i) a

transaction notified in accordance with DTR 3.1.2 R,

(ii) a disclosure made in accordance

LR 9.8.6R(1) or

(iii) a disclosure made in accordance with section 793 of the Companies Act (2006).

(i).

3.

Name of person discharging managerial

responsibilities/director

ASSICURAZIONI GENERALI S.p.A. DIRECTOR OF THE ISSUER.

4.

State whether notification relates to a person

connected with a person discharging managerial responsibilities/director named in 3 and identify the connected person

THIS NOTIFICATION RELATES TO ASSICURAZIONI GENERALI S.P.A. AND THE FOLLOWING CONNECTED PERSONS WHICH ARE SUBSIDIARIES OF ASSICURAZIONI GENERALI S.P.A.: GENERALI ESPAÑA S.A. DE SEGUROS Y REASEGUROS, GENERALI WORLDWIDE INSURANCE CO. LTD (GUERNSEY), GENERALI VERSICHERUNG AG, COSMOS LEBENSVERSICHERUNGS AG, CENTRAL KRANKENVERSICHERUNG AG, AACHENMÜCHENER LEBENSVERSICHERUNG AG AND GENERALI VERSICHERUNG AG.

5.

Indicate whether the notification is in respect of a holding of the person referred to in 3 or 4 above or in respect of a nonbeneficial

interest 1

AS IN 4 ABOVE.

6.

Description of shares (including class), debentures or derivatives or financial instruments relating to shares

ORDINARY SHARES OF 0.50 EURO NOMINAL VALUE.

7.

Name of registered shareholders(s) and, if more than one, the number of shares held by each of them

ASSICURAZIONI GENERALI S.P.A. AND ITS SUBSIDIARIES HAVE AFTER THE TRANSACTIONS DESCRIBED IN THIS NOTIFICATION A TOTAL OF 67,820,935 SHARES, WHICH REPRESENT 0.869% OF THE ISSUER'S SHARE (CAPITAL NOT TAKING INTO ACCOUNT TREASURY STOCK).

8.

State the nature of the transaction

DISPOSAL BY GENERALI ESPAÑA S.A. DE SEGUROS Y REASEGUROS ON 30 JULY 2010 OF 1,000,000 SHARES.

DISPOSAL BY GENERALI ESPAÑA S.A. DE SEGUROS Y REASEGUROS ON 06 AUGUST 2010 OF 6,089,875 SHARES.

DISPOSAL BY GENERALI ESPAÑA S.A. DE SEGUROS Y REASEGUROS ON 09 AUGUST 2010 OF 1,500,000 SHARES.

DISPOSAL BY ASSICURAZIONI GENERALI S.P.A. ON 09 AUGUST 2010 OF 200,000 SHARES.

DISPOSAL BY ASSICURAZIONI GENERALI S.P.A. ON 09 AUGUST 2010 OF 200,000 SHARES.

PURCHASE BY GENERALI WORLDWIDE INSURANCE CO. LTD (GUERNSEY) ON 09 AUGUST 2010 OF 26,385 SHARES.

DISPOSAL BY ASSICURAZIONI GENERALI S.P.A. ON 10 AUGUST 2010 OF 197,277 SHARES.

DISPOSAL BY ASSICURAZIONI GENERALI S.P.A. ON 10 AUGUST 2010 OF 200,000 SHARES.

DISPOSAL BY ASSICURAZIONI GENERALI S.P.A. ON 10 AUGUST 2010 OF 200,000 SHARES.

DISPOSAL BY GENERALI ESPAÑA S.A. DE SEGUROS Y REASEGUROS ON 10 AUGUST 2010 OF 2,044,936 SHARES.

DISPOSAL BY GENERALI ESPAÑA S.A. DE SEGUROS Y REASEGUROS ON 11 AUGUST 2010 OF 3,544,936 SHARES.

DISPOSAL BY GENERALI VERSICHERUNG AG ON 13 AUGUST 2010 OF 26,250 SHARES.

DISPOSAL BY GENERALI VERSICHERUNG AG ON 13 AUGUST 2010 OF 192,500 SHARES.

DISPOSAL BY COSMOS LEBENSVERSICHERUNGS AG ON 13 AUGUST 2010 OF 657,500 SHARES.

DISPOSAL BY CENTRAL KRANKENVERSICHERUNG AG ON 13 AUGUST 2010 OF 593,750 SHARES.

DISPOSAL BY AACHENMÜCHENER LEBENSVERSICHERUNG AG ON 13 AUGUST 2010 OF 285,625 SHARES.

DISPOSAL BY GENERALI VERSICHERUNG AG ON 16 AUGUST 2010 OF 96,250 SHARES.

DISPOSAL BY GENERALI VERSICHERUNG AG ON 16 AUGUST 2010 OF 13,125 SHARES.

DISPOSAL BY GENERALI VERSICHERUNG AG ON 16 AUGUST 2010 OF 13,125 SHARES.

DISPOSAL BY GENERALI VERSICHERUNG AG ON 16 AUGUST 2010 OF 96,250 SHARES.

DISPOSAL BY CENTRAL KRANKENVERSICHERUNG AG ON 16 AUGUST 2010 OF 296,875 SHARES.

DISPOSAL BY CENTRAL KRANKENVERSICHERUNG AG ON 16 AUGUST 2010 OF 296,875 SHARES.

DISPOSAL BY AACHENMÜCHENER LEBENSVERSICHERUNG AG ON 16 AUGUST 2010 OF 142,815 SHARES.

DISPOSAL BY AACHENMÜCHENER LEBENSVERSICHERUNG AG ON 16 AUGUST 2010 OF 142,810 SHARES.

DISPOSAL BY COSMOS LEBENSVERSICHERUNGS AG ON 16 AUGUST 2010 OF 328,720 SHARES.

DISPOSAL BY COSMOS LEBENSVERSICHERUNGS AG ON 16 AUGUST 2010 OF 328,717 SHARES.

9.

Number of shares, debentures or financial

instruments relating to shares acquired

SEE 8 ABOVE.

10.

Percentage of issued class acquired (treasury shares of that class should not be taken into account when calculating percentage)

0.000%

11.

Number of shares, debentures or financial

instruments relating to shares disposed

SEE 8 ABOVE.

12.

Percentage of issued class disposed (treasury shares of that class should not be taken into account when calculating percentage)

0.228%

13.

Price per share or value of transaction

DISPOSAL BY GENERALI ESPAÑA S.A. DE SEGUROS Y REASEGUROS ON 30 JULY 2010 OF 1,000,000 SHARES @ 10.05 EURO PER SHARE.

DISPOSAL BY GENERALI ESPAÑA S.A. DE SEGUROS Y REASEGUROS ON 06 AUGUST 2010 OF 6,089,875 SHARES @ 10.24 EURO PER SHARE.

DISPOSAL BY GENERALI ESPAÑA S.A. DE SEGUROS Y REASEGUROS ON 09 AUGUST 2010 OF 1,500,000 SHARES @ 10.24 EURO PER SHARE.

DISPOSAL BY ASSICURAZIONI GENERALI S.P.A. ON 09 AUGUST 2010 OF 200,000 SHARES @ 10.23 EURO PER SHARE.

DISPOSAL BY ASSICURAZIONI GENERALI S.P.A. ON 09 AUGUST 2010 OF 200,000 SHARES @ 10.22 EURO PER SHARE.

PURCHASE BY GENERALI WORLDWIDE INSURANCE CO. LTD (GUERNSEY) ON 09 AUGUST 2010 OF 26,385 SHARES @ 10.35 EURO PER SHARE.

DISPOSAL BY ASSICURAZIONI GENERALI S.P.A. ON 10 AUGUST 2010 OF 197,277 SHARES @ 10.18 EURO PER SHARE.

DISPOSAL BY ASSICURAZIONI GENERALI S.P.A. ON 10 AUGUST 2010 OF 200,000 SHARES @ 10.13 EURO PER SHARE.

DISPOSAL BY ASSICURAZIONI GENERALI S.P.A. ON 10 AUGUST 2010 OF 200,000 SHARES @ 10.19 EURO PER SHARE.

DISPOSAL BY GENERALI ESPAÑA S.A. DE SEGUROS Y REASEGUROS ON 10 AUGUST 2010 OF 2,044,936 SHARES @ 10.17 EURO PER SHARE.

DISPOSAL BY GENERALI ESPAÑA S.A. DE SEGUROS Y REASEGUROS ON 11 AUGUST 2010 OF 3,544,936 SHARES @ 9.91 EURO PER SHARE.

DISPOSAL BY GENERALI VERSICHERUNG AG ON 13 AUGUST 2010 OF 26,250 SHARES @ 9.61 EURO PER SHARE.

DISPOSAL BY GENERALI VERSICHERUNG AG ON 13 AUGUST 2010 OF 192,500 SHARES @ 9.61 EURO PER SHARE.

DISPOSAL BY COSMOS LEBENSVERSICHERUNGS AG ON 13 AUGUST 2010 OF 657,500 SHARES @ 9.61 EURO PER SHARE.

DISPOSAL BY CENTRAL KRANKENVERSICHERUNG AG ON 13 AUGUST 2010 OF 593,750 SHARES @ 9.61 EURO PER SHARE.

DISPOSAL BY AACHENMÜCHENER LEBENSVERSICHERUNG AG ON 13 AUGUST 2010 OF 285,625 SHARES @ 9.61 EURO PER SHARE.

DISPOSAL BY GENERALI VERSICHERUNG AG ON 16 AUGUST 2010 OF 96,250 SHARES @ 9.72 EURO PER SHARE.

DISPOSAL BY GENERALI VERSICHERUNG AG ON 16 AUGUST 2010 OF 13,125 SHARES @ 9.62 EURO PER SHARE.

DISPOSAL BY GENERALI VERSICHERUNG AG ON 16 AUGUST 2010 OF 13,125 SHARES @ 9.72 EURO PER SHARE.

DISPOSAL BY GENERALI VERSICHERUNG AG ON 16 AUGUST 2010 OF 96,250 SHARES @ 9.62 EURO PER SHARE.

DISPOSAL BY CENTRAL KRANKENVERSICHERUNG AG ON 16 AUGUST 2010 OF 296,875 SHARES @ 9.72 EURO PER SHARE.

DISPOSAL BY CENTRAL KRANKENVERSICHERUNG AG ON 16 AUGUST 2010 OF 296,875 SHARES @ 9.62 EURO PER SHARE.

DISPOSAL BY AACHENMÜCHENER LEBENSVERSICHERUNG AG ON 16 AUGUST 2010 OF 142,815 SHARES @ 9.72 EURO PER SHARE.

DISPOSAL BY AACHENMÜCHENER LEBENSVERSICHERUNG AG ON 16 AUGUST 2010 OF 142,810 SHARES @ 9.62 EURO PER SHARE.

DISPOSAL BY COSMOS LEBENSVERSICHERUNGS AG

ON 16 AUGUST 2010 OF 328,720 SHARES @ 9.72 EURO PER SHARE.

DISPOSAL BY COSMOS LEBENSVERSICHERUNGS AG

ON 16 AUGUST 2010 OF 328,717 SHARES @ 9.62 EURO PER SHARE.

14.

Date and place of transaction

SPAIN, SEE 8 ABOVE.

15.

Total holding following notification and total percentage holding following notification (any treasury shares should not be taken into account when calculating percentage)

67,820,935 SHARES REPRESENTING 0.869% OF THE ISSUER'S SHARE (CAPITAL NOT TAKING INTO ACCOUNT TREASURY STOCK).

16.

Date issuer informed of transaction

26 AUGUST 2010.

17.

Date of grant

18.

Period during which or date on which exercisable

19.

Total amount paid (if any) for grant of the option

20.

Description of shares or debentures involved (class and number)

21.

Exercise price (if fixed at time of grant) or

indication that price is to be fixed at the time of exercise

22.

Total number of shares or debentures over which options held following notification

23.

Any additional information

NONE.

24.

Name of contact and telephone number for queries

JESUS MARIA DIAZ DE MERA

+(34) 912-897-738

Name of authorised official of issuer responsible for making notification

JOSE MANUEL DE ARALUCE

Date of notification

 26 AUGUST 2010

(1)

An issuer making a notification in respect of a transaction relating to the shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.

(2)

An issuer making a notification in respect of a derivative relating the shares of the issuer should complete boxes 1 to 4, 6, 8, 13, 14, 16, 23 and 24.

(3)

An issuer making a notification in respect of options granted to a director/person discharging managerial responsibilities should complete boxes 1 to 3 and 17 to 24.

(4)

An issuer making a notification in respect of a financial instrument relating to the shares of the issuer (other than a debenture) should complete boxes 1 to 4, 6, 8, 9, 11, 13, 14, 16, 23 and 24.