Tribe Technology set to deliver healthy pipeline of orders from Tier-One miners. Watch the video here.
https://www.jpost.com/health-science/five-israeli-companies-fighting-for-a-covid-19-cure-659456
P1
Tel Aviv’s “miracle” cure
Since Tel Aviv’s Sourasky Medical Center announced earlier this month that it managed to “cure” 29 out of 30 moderate-to-severe COVID-19 patients who were administered a treatment developed by the hospital, it has received international attention.
The patients, who were part of a Phase I trial, recovered from the disease and were released within three to five days, according to Prof. Nadir Arber, whose lab developed the treatment.
Since then, another five patients have received it, showing the same results.
The patients were given Arber’s EXO-CD24 COVID-19 treatment, which is based on CD24-enriched exosomes and is meant to fight the cytokine storm.
Exosomes are responsible for cell-to-cell communication. In this case, they deliver the CD24 protein to the lungs, which helps calm down the immune system.
Arber said that a cytokine storm develops in between 5% and 7% of COVID-19 patients within five to seven days.
“This protein is located on the surface of cells and has a well-known and important role in regulating the immune system,” explained Dr. Shiran Shapira, who works in Arber’s lab.
Arber said that in all cases that oxygen levels increased, respiratory rates and cytokines in the blood decreased. And, subjectively, the patients said they felt better. The primary end point of the Phase I study was safety.
“We are now sure about the safety,” he said. “We have a good feeling about efficacy.”
Arber has been researching exosomes for the better part of two decades. He said it took about six months from the time the idea of using this treatment in the battle against COVID-19 was raised until it was first tested in humans.
“Me and my team have been at the hospital every day, including Friday and Saturday, for the last six months,” he said. “We are now full of excitement and hope that we can find a cure for this pandemic.”
The treatment is inhaled once a day for a few minutes at a time for five days. It directly targets the lungs, the site of the storm, as opposed to other treatments that could be given systemically and hence cause severe side effects, Arber explained.
The hospital is now moving forward with additional clinical trials.
The largest hospital in Greece is hoping to take part in the next trial, following a meeting between Greek Prime Minister Kyriakos Mitsotakis and Prime Minister Benjamin Netanyahu earlier this month.
During a press conference with the Greek leader, Netanyahu held up a vial of Arber’s treatment and called it a “miracle drug.”
https://www.google.co.uk/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&ved=2ahUKEwi59_6OjO_uAhWFgVwKHfJxBfAQFjACegQIBBAC&url=https%3A%2F%2Fwww.mdpi.com%2F2077-0383%2F10%2F4%2F783%2Fpdf&usg=AOvVaw2J6A3kIjB_VJyjWZXMDcRm
FIG 1, room for our 1801 ;)
AGILE Platform, they will want to know of anything with potential in preclinical that could be used against Covid.
RNS is a heads up, Sareum most likely already been in contact with them with time lines, whether in or out, Agile wont want to be dilly dallying on an application process if 1801 works. Trials would need planning etc which all take time. ..
Fast track will be as soon as 1801 results land, AIMHO ;)
Full of JAK-STAT stuff......
good reading
P14 & 15 ,
7. conclusion,
Fig 2. explained
Shouldn't be to long before Sareum feature in Table 2,
GLALTH's ;)
click link, then download PDF
https://www.mdpi.com/1422-0067/22/4/1906
For those interested..
Long interesting read, value in these indications, google translate it.
https://www.google.co.uk/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&cad=rja&uact=8&ved=2ahUKEwiZr6yM4t_uAhWLi1wKHcltDAQ4ChAWMAB6BAgBEAI&url=https%3A%2F%2Fnews.sina.com.tw%2Farticle%2F20210210%2F37623146.html&usg=AOvVaw3Mrf3jSSjMa3l9rRU5wYdc
just looked, yes is relevant WIP, no tox for us at present, all bodes well.
Lets hope we get the support we need to get these molecules to trial, fast tracked would be nice..;)
TYK2 gets mentioned
https://www.google.co.uk/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&cad=rja&uact=8&ved=2ahUKEwidjoDemt3uAhVkoFwKHcl3AlEQFjAPegQICxAC&url=https%3A%2F%2Fwww.academia.edu%2F44956430%2FNatural_and_Nature_Derived_Products_Targeting_Human_Coronaviruses&usg=AOvVaw3V_aVLd0kkl2HonGhBQS7o
and TYK2 mentioned again..
Thank you Fadec92, more competition then, which is expected now TYK2 is starting to become more in focus.
I've emailed this link to Dr Mitchell, hopefully will give him a need for more urgency...
Validation for TYK2...
https://www.google.co.uk/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&cad=rja&uact=8&ved=2ahUKEwi_r6bkht3uAhUIYsAKHSosCC0QFjABegQIAhAC&url=https%3A%2F%2Fwww.immunohorizons.org%2Fcontent%2Fimmunohorizon%2F5%2F2%2F70.full.pdf&usg=AOvVaw2b08RnbSfduaDhKj_cgVjD
But is this competition from Singapore University...
A patent on TYK2 ASOs has been filed by Nanyang Technological
University with the authors as inventors.
Scanned through but what are they patenting exactly? "TYK2 ASOs" is this not the method, couldn't see any specific molecules, or have I missed something?..
Coronavirus will be for ever, could be 1000's mutations in time. the need for therapies will become dire..
https://www.sciencedirect.com/science/article/pii/S0025619620313847
T2, think you may have hit the nail on the head, they must have their eyes on us to join their party
https://mediacenter.23andme.com/press-releases/23andme-signs-a-strategic-agreement-with-almirall/
is the method
https://pubmed.ncbi.nlm.nih.gov/33542028/
GLALTH's
JAK1 Info..
This gene has been reviewed for its involvement in coronavirus biology, and is relevant for COVID-19 treatment.
https://www.ncbi.nlm.nih.gov/gene/3716
nice, relevant for covid treatment, think Tims price tag for licencing will be worth the wait