IntelliAM aiming for significant growth with £5 million Aquis IPO. Watch the video here.
London South East prides itself on its community spirit, and in order to keep the chat section problem free, we ask all members to follow these simple rules. In these rules, we refer to ourselves as "we", "us", "our". The user of the website is referred to as "you" and "your".
By posting on our share chat boards you are agreeing to the following:
The IP address of all posts is recorded to aid in enforcing these conditions. As a user you agree to any information you have entered being stored in a database. You agree that we have the right to remove, edit, move or close any topic or board at any time should we see fit. You agree that we have the right to remove any post without notice. You agree that we have the right to suspend your account without notice.
Please note some users may not behave properly and may post content that is misleading, untrue or offensive.
It is not possible for us to fully monitor all content all of the time but where we have actually received notice of any content that is potentially misleading, untrue, offensive, unlawful, infringes third party rights or is potentially in breach of these terms and conditions, then we will review such content, decide whether to remove it from this website and act accordingly.
Premium Members are members that have a premium subscription with London South East. You can subscribe here.
London South East does not endorse such members, and posts should not be construed as advice and represent the opinions of the authors, not those of London South East Ltd, or its affiliates.
Science is not your strong point is it thorn. Let’s get this straight, are you trying to tell us that the goal here should be to have all the ava6000 cleaved at the tumour site?
I'll help you with another question thorn. If you have a body of volume A and a sub-body inside this of volume B. If a liquid substance is injected into body A and it distributes evenly around bodies A and B, and we want the concentration of this substance to be C in body B, what must the concentration of this substance be in A to reach the desired concentration in B?
Enough to do the job Gje.
If too much is just flushed out then that's not great.
Perhaps why Avacta have told us they're working on half-life extension molecutes?
So that it hangs around longer in the body to increase tumour exposure times and likely clinical outcomes.
Molecular size however will have implications on tumour penetration perhaps?
It's complicated, the 'it works' narrative just looks more lame every time they do a presentation, or alter the trial design, or timelines slip or the share price continues to slide.
#avct on twitter to see thornogson motivations
Please try and answer the question thorn.
I'd need to know the Plasma half life and the time of interaction at the FAP interface?
What's the FAP concentration and how long does the AVA6000 molecule take to fully interact with the FAP molecule to be cleaved and how long then until the FAP molecule is available again to cleave the next AVA6000 molecule?
I think it might be beyond me truth be told, but if Avacta are working on half-life extension molecules I think it's safe to assume that they feel the half life of Pre|Cision as it stands could be improved?
Thorn are you still getting paid by Winnniifrith? If so that makes sense the dedication you have. Deary me.
Eggy: 'I think it might be beyond me truth be told,...' - Well if that isn't the understatement of the decade!! Whahahahaha
Trolls don't answer questions, they only post rollocks and questions. Most popular thread ever, it's still going... 200+ replies, majority to garbled idiocy. As it turns out the subject of the thread is the most important. They shared pk data from the 3w trial, that tells how much is in the blood over time and we've been told 100x more in the TME for mid and high FAP, all whilst reducing side effects. It works.
Yes it probably is beyond you.
In order to get volume B up to the concentrations of A, then you will need to saturate A to the same level as C. It is a necessary requirement to sacrifice the majority of the injected AVA6000 in order to raise the concentration levels in the entire system. This is also the case for straight doxorubicin, the majority of it will not be reaching the the tumour, but alas it is not inert, so that superfluous dox goes on to kill healthy cells.
Now, on half life. It is true that for both straight dox and ava6000, that the majority is flushed out of the system without reaching the tumour. So when you say:
"If too much is just flushed out then that's not great."
then no, you are missing the point here completely. It is a necessary part of the mechanism of action that the majority will be eventually be excreted.
I'm sure Avacta are working on ways to modulate the precision based medicines, of course they will, they're aiming at leveraging the precision platform with many different molecules, which will all have their own pharmacokinetics. A mechanism to module half life will be another tool in the box.
We know no MTD was found so not a large amount of dox was cleaved outside of the TME. Ideally we would have had biopsies taken say 6 hours after dosing which will have likely shown more dox in both the tumour and plasma. The fact the biopsies were taken 24 hours after is a real plus and shows the relatively short half life isn’t an issue. Of course it can be improved upon for other warheads and the patents suggest this is the case (pipeline update will be super). We have very large amounts of dox in the tumours 24 hours after dosing and one of our independent oncologist’s amazed at the amount. Exciting for sure. Thorn could try and spread FUD more easily if the biopsies were taken a few hours after dosing but we got 24 hours.
Gje306
That is so much crap. You are talking as if it’s osmosis. It isn’t. FAP is cleaving the AVA6000. There isn’t AVA6000 in the tumour. You are talking rot as usual
That’s you done in 👍
https://x.com/MylesMcNulty/status/1808061031421235643
Touk, you are just exposing your limited ability to think this through. Read it again. I'll repeat. In order to get the concentration of ava6000 at the tumour site to your desired concentration c, you'll have to raise the levels of ava6000 around the entire body to c. This can be maintained for some time at this level by reaching a steady state of ava6000 in and ava6000 out. The majority of ava6000 will be excreted without it passing by the tumour. Any that does can be cleaved by the fap.
The important metric, and try to focus on this, is the amount of dox that is cleaved and ends up in the tumour itself.
Yes it's not a passive process but an active one with blood pumping blood through tissues.
Some will meet FAP along its travels but most won't and for the AVA6000 that does there's a whole load of variables just there at the FAP interface, how quickly does it happen? How soon is the FAP free to cleave the next AVA6000 molcule?
This will all be important to Avacta trying to calculate what dose and frequency will maximise the Dox deposition in FAP +ve tumours to achieve the best possible results.
Fluid volume A and B!
Blood pumping AVA6000
It doesn't matter how much is excreted as long as the dox is absorbed into the tumour at sufficient concentrations to be effective.
Thornogson=Eggy=Paid troll - see NFT's post today @ 11:11
A sufficient concentration to be effective......
for a sufficient length of time to be effective too Gje?
Thorn I hope you're getting paid per post. You said earlier, dox will be dox. Dox is cleared from the body in 24-48 hours. We had huge amounts in the TME after 24 hours so as you said dox will behave like dox. We are getting more dox into the tumour and it remained there after 24 hours so bodes well.
Doxorubicin, also known as Adriamycin or Rubex, is a chemotherapy medication used to treat various cancers, including leukemia, lymphoma, Wilms’ tumor, neuroblastoma, sarcoma, breast, gastric, bladder, lung, and thyroid cancer1. It works by interrupting DNA copying in cancer cells, leading to their death and slowing or stopping tumor growth. When administered intravenously, doxorubicin may cause a feeling of burning and pain. The medication is cleared from your body within 1-2 days after each dose, and you may notice orange or reddish urine during that time2. If you experience any symptoms like shortness of breath, chest pain, or irregular heartbeats, seek medical attention promptly. Additionally, certain foods and medications can affect its blood levels and effectiveness, so be cautious and inform your healthcare provider about all medications and supplements you take1. Remember to follow your care team’s guidance and report any concerning side effects.
Thorn, once dox is absorbed into tissue, what is the half life?
Thornogson=Eggy=Paid troll - see NFT's post today @ 11:11
“TW has got this so so so SO wrong”
All part of his Freeman of the Land schtick
So unconcerned about the lethal effect of Covid, he took his wife and young son on a three hour flight to Greece, in the early days of Covid before anyone knew the severity of the disease, least of all him
His animus against Avacta started with the LFT, helped along with a following wind by Smith’s bloviating
He’s now telling his followers to vote Reform , when anyone with half a brain knows that is a vote for Starmer.
All reminiscent of Goldsmith’s Referendum Party, which split the Tory vote, letting in Blair
Present polls
Labour 40%
Tories 20%
Reform 20%
Truthfully the bar is so low to replace Dox. That even if the half life is not optimal as some posters suggest here, the fact the safety profile and increased cycles which are providing early efficacy results with therapeutic levels of Dox in the TME, still means this will replace the 50yr old chemo drug. It doesn’t have to perfect!